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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 89 (1982), S. 167-172 
    ISSN: 1437-1596
    Keywords: Sudden infant death ; Candida albicans ; Intestinal alcohol production ; Plötzlicher Säuglingstod ; Candida albicans ; Alkoholproduktion, im Darm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung In einigen Fällen vom Syndrom des plötzlichen Säuglingstodes (SIDS) wurde befunden, daß die Darmflora vonCandida albicans dominiert war. Mikrobiologische Untersuchungen der verschiedenen Organe zeigten gelegentlich Vorkommen von verschiedenen Candida-Arten, aber nicht in der Form von massivem Wachstum wie bei Sepsis. Es besteht kein Grund zur Annahme, daß die Wirksamkeit von Hefen, in erster Linie vonCandida albicans, ein mitwirkender Faktor beim Vorkommen von SIDS ist. Es wurde festgestellt, daßCandida albicans Alkohol aus Glukose in einer Geschwindigkeit von höchstens 1 mg Alkohol pro Gramm Darminhalt je Stunde produziert. Daraus wird gefolgert, daß die Darmproduktion von Alkohol in vivo in Fällen, die eine vonCandida albicans dominierte Darmflora aufweisen, die normale alkoholmetabolisierende Fähigkeit der Leber nicht übertreffen wird. Meßbare Konzentrationen von Alkohol im Blut sind daher in solchen Fällen nicht zu erwarten.[/ p]
    Notes: Summary In some cases of sudden infant death syndrome (SIDS) the intestinal flora was found to be dominated byCandida albicans. Microbiologic investigations of the various organs showed the occasional presence of different Candida species, but not in the form of massive growth as in sepsis. There is no basis to assume that the activity of yeasts, first of all ofCandida albicans, is a contributory factor in the occurrence of SIDS. Candida albicans was shown to produce alcohol from glucose at a rate of maximally 1 mg of alcohol per gram of intestinal content per hour. It is concluded that the intestinal production of alcohol in vivo from cases showing aCandida albicans dominated intestinal flora will not be able to surpass the normal alcohol metabolizing capacity of the liver. Thus, measurable concentrations of alcohol in the blood from such cases cannot be expected.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 150 (1991), S. 835-838 
    ISSN: 1432-1076
    Keywords: Neurofibromatosis type 1 ; Optic glioma ; Natural history ; Visual evoked potential
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Over a 24-year period, optic gliomas were found in 29 children, 16 of whom had neurofibromatosis type 1 (NF-1). These 16 children comprised 21% of all children referred for management of NF-1 and its complications. The finding of optic glioma led to the diagnosis of NF-1 in 4 children. The mean age at diagnosis of optic glioma in NF-1 children was 6.4 years, and the average estimated duration of visual symptoms prior to diagnosis was 2.1 years. Most optic gliomas in NF-1 children were ascertained because of a visual complaint (69%), and an even greater number of children (88%) had an abnormal ophthalmological examination. The optic chiasm was involved in 75% of the patients. All of the seven children with optic glioma examined by visual evoked potential had an abnormal response ipsilateral to the tumour. The majority of the children received radiation therapy. After a mean follow up period of 5.8 years no deaths had occurred due to optic glioma, but in 35% of the children vision was worse. We conclude that optic glioma is a common, serious complication in NF-1 children. Routine care of such patients should include regular noninvasive investigations aimed at detecting lesions of the optic pathway.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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