ISSN:
1572-8854
Schlagwort(e):
Antisense oligonucleotides
;
oxathiaphospholanes
;
dithiaphospholanes
;
absolute configuration
;
NMR and XRD studies
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Geologie und Paläontologie
,
Physik
Notizen:
Abstract Two “thiophospholane” derivatives of cholesterol: 2-cholesteryl-2-thio-1,3,2-oxathiaphospholane (1) and 2-cholesteryl-2-thio-1,3,2-dithiaphospholane (2) were synthesized as new reagents for introducing a cholesteryl moiety at the 5′-end of oligonucleotidesvia the phosphorothioate or phosphorodithioate bond. Compounds1 and2 were subjected to structural studies by X-ray methods. Both compounds crystallized in the orthorhombic system, space group P212121,1 witha=6.283(1) Å,b=12.067(1) Å,c=38.983(3) Å,2 witha=6.371(1) Å,b=11.971(1) Å andc=39.502(3) Å. The five-membered heterocyclic rings of both compounds attain a half-chair conformation in the solid state. In structures of1 and2 a disorder of some atoms is observed. The absolute configuration at the phosphorus atom in1 of the components of diastereoisomeric mixture has been established.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02018694
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