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  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of dopamine-activated adenylate cyclase and dopamine binding by opiate receptors in rat striatum (1983)
    Springer
    Cellular and molecular neurobiology 3 (1983), S. 17-26 
    Details
    ISSN: 1573-6830
    Keywords: dopamine ; opiates ; adenylate cyclase ; striatum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Low-affinity (micromolar)3H-dopamine binding was measured under conditions which permitted dopamine activation and opiate inhibition of adenylate cyclase in rat striatal membranes. Opiate drugs and peptides inhibited the dopamine binding in the presence of both GTP5 and Gpp(NH)p. Opiate inhibition of adenylate cyclase was, however, observed only in the presence of GTP. 2. It is suggested that the dopamine D1 receptor in striatum may be modulated by the opiate delta receptor through a shared guanine nucleotide binding subunit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00734995
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Modulation of muscarinic receptor-mediated adenylate cyclase and phospholipase C responses in rat retina (1991)
    Springer
    Cellular and molecular neurobiology 11 (1991), S. 455-462 
    Details
    ISSN: 1573-6830
    Keywords: muscarinic receptors ; adenylate cyclase ; cyclic AMP ; phosphoinositide hydrolysis ; phorbol esters ; pertussis toxin ; cholera toxin ; rat retina
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Agonist activation of rat retina muscarinic receptors results in suppression of cyclic AMP (cAMP) generation and enhanced phosphoinositide hydrolysis. 2. Pharmacological manipulations that elevate cAMP or stable analogues of cAMP attenuate the acetylcholine (ACh)-induced enhancement of phosphoinositide hydrolysis. We postulate that cross-talk between adenylate cyclase and phospholipase C signal transducing systems probably exists in rat retina, as has been described for other systems. 3. Intraocular administration of pertussis toxin attenuated the response of both adenylate cyclase and phospholipase C to muscarinic stimulation, suggesting that some retinal muscarinic receptors are apparently coupled to their effector systems via pertussis toxin sensitive G proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00734809
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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