ISSN:
1573-7217
Keywords:
adjuvant therapy
;
breast cancer
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The Southwest Oncology Group in a prospective randomized study compared one year of adjuvant combination chemotherapy with continuous CVFVP (cyclophosphamide, methotrexate, 5-fluorouracil, vincristine, and prednisone) to two years of intermittent L-phenylalanine mustard (L-PAM) in women with operable breast cancer with histologically positive axillary lymph nodes. In fully and partially evaluable patients with a 68-month median follow-up, treatment failures have occurred in 27% of 172 receiving CMFVP and 47% of 186 women given L-PAM (p = 0.002). The advantage for women receiving CMFVP was seen for all subsets regardless of menopausal status except among women who were premenopausal and had 1–3 positive nodes. Based on this study, a second study was implemented using both the estrogenreceptor (ER) content of the primary tumor and axillary nodal status to select therapy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01855124
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