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Digitale Medien

Severe toxic reaction to tinidazole (1983)

Aase, S. ; Olsen, A. K. ; Roland, M. ; [weitere]

Springer

European journal of clinical pharmacology 24 (1983), S. 425-427

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Details

ISSN: 1432-1041

Schlagwort(e): tinidazole ; complement activation ; toxicity ; adverse reaction ; healthy volunteer

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary A physician aged 44 years participated as a volunteer in pharmacokinetic studies with tinidazole (FASIGYN, Pfizer). He received 1600 mg of the drug as an intravenous infusion over 80 min. Shortly afterwards, he fainted and was unconscious for about 10 s. The attack was followed by low blood pressure, nausea and tiredness for several h. The serum concentration of tinidazole was 35.4 mg/l when the attack started. Blood tests showed a normal immunoglobulin E level, and a transient fall in the concentration of complement factor C3 after the infusion. It is concluded that tinidazole caused an acute toxic reaction with subsequent activation of complement factors.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00610066

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