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  • 1
    Electronic Resource
    Electronic Resource
    Translation and validation of the Standard Chinese version of the EORTC QLQ-C30 (2000)
    Springer
    Quality of life research 9 (2000), S. 129-137 
    Details
    ISSN: 1573-2649
    Keywords: EORTC QLQ-C30 ; Gynecological cancer ; Psychometric property ; Quality of life ; Standard Chinese
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The majority of quality of life (QOL) questionnaires have been developed and used in English-speaking or Western European countries. The aims of this study were to provide the Standard Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ-C30 version 2.0), and evaluate its psychometric properties. The translation process included independent translation, back translation, a pilot test with gynecological cancer patients, and a review and approval by the original developers. Participants in the major study included gestational trophoblastic disease patients (n = 68), ovarian cancer patients (n = 105), and other types of gynecological cancer patients (n = 18). The average completion time of the Standard Chinese version was 8.1 ± 2.9 min. All item-subscale correlation coefficients exceeded the criterion of item-convergent validity (r 〉 0.40) except item 1, 5, 20, and 25, and all items correlated significantly higher with their own subscale than with other subscales except item 1, 20, and 25. The correlation coefficients among all subscales were significant but modest (r = 0.40–0.70). Seven out of nine subscales met the minimal standards of reliability (Cronbach's α 〉 0.70). In conclusion, the Standard Chinese version of the EORTC QLQ-C30 is a valid instrument overall in assessing the QOL of Chinese gynecological cancer patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008981520920
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  • 2
    Electronic Resource
    Electronic Resource
    Surface Active Agents as Enhancers of Alveolar Absorption (2000)
    Springer
    Pharmaceutical research 17 (2000), S. 38-41 
    Details
    ISSN: 1573-904X
    Keywords: absorption ; aerosols ; surface active agents ; drug administration routes ; drug formulation ; radioactive imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. Small solutes which are deposited in the alveoli by aerosolinhalation will be absorbed across the alveolo-capillary barrier.Inhalation of dioctyl sodium sulfosuccinate (DOSS) enhances absorptionwhile having little or no effect on lung function, suggesting that surfaceactive agents may be used as enhancers of alveolar absorption ofinhaled pharmaceuticals. The purpose of this study was to examinethe effects of a selection of different surface active agents onalveolar absorption. Methods. The absorption of 99mTc-diethylene triamine pentaacetate(99mTc-DTPA) from the lungs was studied in rabbits. We studied fivedifferent surface active agents: DOSS, sodium glycodioxycholate(GDCA), sodium lauryl sulphate (NaLS), lysophosphatidyl choline(LPC) and polyoxyethylene-23-laurylether (P23LE). Results. DOSS and GDCA both dramatically enhanced the absorptionof 99mTc-DTPA. There was a moderate effect of NaLS, no significanteffect of LPC and P23LE reduced the rate of absorption. None of thecompounds affected gas exchange or lung compliance. Conclusions. There is a wide spectrum of effects of inhaled surfaceactive agents on the alveolar absorption of 99mTc-DTPA. Ioniccompounds such as DOSS and GDCA have the greatest effect, and furtherstudies of these classes of surface active agents for use as enhancersof alveolar absorption of pharmaceuticals seem warranted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007562307414
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    Paper (German National Licenses)
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