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Digitale Medien

The selective inactivation of thiol proteasesin vitro andin vivo (1984)

Shaw, Elliott

Springer

The protein journal 3 (1984), S. 109-120

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ISSN: 1573-4943

Schlagwort(e): thiol proteases ; affinity labeling ; protease inhibitors ; diazomethyl ketones

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Abstract Peptidyl diazomethyl ketone derivatives inactivate thiol proteases by affinity labeling. The peptide sequence permits the reagents to be targeted to individual proteases according to their specificity. Alkylation of the active center thiol group takes place. The reagents are not reactive to simple thiols such as mercaptoethanol and appear to inactivate thiol proteases by acting as suicide substrates. Other classes of proteases are not affected. Initial results indicate that peptidyl diazomethyl ketones can also be used to inactivate thiol proteases in vivo.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01024841

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