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Binding of four sulphonamides to human albumin (1976)

Zini, R. ; d'Athis, P. ; Hoareau, A. ; [et al.]

Springer

European journal of clinical pharmacology 10 (1976), S. 139-145

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ISSN: 1432-1041

Keywords: Furosemide ; tolbutamide ; sulfafurazole ; sulfonamidochlorobenzoic acid ; protein binding ; albumin

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The four sulphonamides studied — furosemide, tolbutamide, sulfafurazole and sulfonamidochlorobenzoic acid — bind to human albumin at the same sites but with decreasing affinity. These sites are also common to other drugs, namely acenocoumarin, chlorophenoxyisobutyric acid, phenylbutazone and warfarin. In plasma, the four sulphonamides considered bind mainly to albumin, but also, at higher concentrations, to globulins, to an extent that increases as their affinity for albumin lessens.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00609473

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