ISSN:
1432-0428
Keywords:
Liver
;
protein kinase
;
cyclic AMP
;
alloxan diabetes
;
insulin
;
glucagon
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Liver protein kinase was determined in the absence and presence of cAMP4. Experimental alloxan diabetes resulted in a decrease in total protein kinase (+ cAMP) and an increase in the activity ratio $$\frac{{( - cAMP)}}{{( + cAMP)}}$$ in liver. Insulin treatment of diabetic rats reversed the observed changes in protein kinase in liver. Glucagon administered in vivo to normal rats caused an increase in the activity ratio and a decrease in total protein kinase activity in liver. The changes are similar to those in diabetes. A decrease in the ratio of insulin to glucagon in diabetes may account for the changes in protein kinase observed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00745144
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