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  • Key words. nonlinear dispersive fibers, nonsoliton pulses, onset of oscillations, hyperbolic shocks  (1)
  • althesin  (1)
  • numerical simulation  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    European journal of clinical pharmacology 29 (1985), S. 181-185 
    ISSN: 1432-1041
    Schlagwort(e): althesin ; steroid binding globulins ; drug interaction ; steroid anaesthetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The binding affinities of two steroid anaesthetics, alphaxalone (Alfx) and alphadolone acetate (Alfd), for testosterone-oestradiol-binding globulin (TeBG) and corticosteroid-binding globulin (CBG) were measured in human serum. In 8 male patients, the effect of i.v. administration of Althesin (a mixture of Alfx and Alfd) on the transport of testosterone (T) and cortisol (F) was studied. Both Alfx and Alfd bind to TeBG and CBG with a relatively high affinity (106M−1). A significant change in the percentage of unbound T was observed during Althesin infusion, with no change in total T concentration or in the TeBG binding parameters. The results suggest that by interaction with TeBG binding sites Alfx and/or Alfd displaced T bound to TeBG, and transiently increased the percentage of unbound T. A significant increase in the concentration of F was observed during althesin infusion, while the percentage of unbound F and the CBG binding parameters were unchanged. The dose of Alfx and Alfd used was not sufficient to alter the transport of F during brief althesin anaesthesia in men.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nonlinear science 8 (1998), S. 43-62 
    ISSN: 1432-1467
    Schlagwort(e): Key words. nonlinear dispersive fibers, nonsoliton pulses, onset of oscillations, hyperbolic shocks
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik , Physik
    Notizen: Summary. We study the modulation equations for the amplitude and phase of smoothed rectangular pulse initial data for the defocusing nonlinear Schrodinger (NLS) equation in the semiclassical limit, and show that these equations exhibit shock formation. In this way we identify and explain one source for the onset of pulse oscillations in nonlinear fibers whose transmission is modeled by the semiclassical NLS equation. The onset of pulse ripples predicted here develops on the leading and trailing slopes of a smooth pulse, as a consequence of shock formation in the modulation equations. This mechanism for the onset of pulse ripples is distinct, both in the location and timescale, from the scenario pursued by Kodama and Wabnitz [11]: A piecewise linear pulse evolves for distances O(1) down the fiber, beyond which oscillations develop associated with the vanishing of the upper step of the pulse [10]. Here we show that the scenario in [11] is correct, but specific to pure rectangular pulses ; any smoothing of this data fails to obey their scenario, but rather is described by the results presented here. That is, the semiclassical limit of the NLS equation is highly unstable with respect to smooth regularizations of rectangular data. In our analysis, the onset of oscillations is associated with the location of the maximum gradient of the pulse slopes, and onset occurs on the pulse slopes, at short distances down the fiber proportional to the inverse of this maximum gradient. Explicit upper and lower bounds on the initial shock location are derived. We thereby deduce the onset for this source of pulse degradation scales linearly with the pulse width, and scales with the reciprocal square root of the fiber nonlinear coefficient, the pulse power, and the fiber dispersion coefficient.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Journal of nonlinear science 3 (1993), S. 393-426 
    ISSN: 1432-1467
    Schlagwort(e): nearly integrable PDE ; nonlinear modes ; modulation equations ; numerical simulation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik , Physik
    Notizen: Summary The purpose of this paper is the derivation of reduced, finite-dimensional dynamical systems that govern the near-integrable modulations ofN-phase, spatially periodic, integrable wavetrains. The small parameter in this perturbation theory is the size of the nonintegrable perturbation in the equation, rather than the amplitude of the solution, which is arbitrary. Therefore, these reduced equations locally approximate strongly nonlinear behavior of the nearly integrable PDE. The derivation we present relies heavily on the integrability of the underlying PDE and applies, in general, to anyN-phase periodic wavetrain. For specific applications, however, a numerical pretest is applied to fix the truncation orderN. We present one example of the reduction philosophy with the damped, driven sine-Gordon system and summarize our present progress toward application of the modulation equations to this numerical study.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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