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  • 1
    Electronic Resource
    Electronic Resource
    Evaluation of the efficacy and tolerance of the antiarrhythmic agent transcainide (R 54718) (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 449-456 
    Details
    ISSN: 1432-1041
    Keywords: transcainide ; antiarrhythmic drugs ; cardiac arrhythmias ; adverse effects ; ventricular arrhythmias ; supraventricular arrhythmias
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The antiarrhythmic efficacy of transcainide has been studied in 41 patients. It abolished ventricular arrhythmias in 10 out of 12 patients after i.v. administration and in 11 out of 14 after oral administration. It also reduced ventricular arrhythmias during recovery from exercise. The maximum intravenous dose prolonged the PR-interval by 43% and QRS-duration by 37%. Side-effects observed in 6 out of 41 patients included Mobitz Type I AV block, complete bundle branch block, hypotension and increased arrhythmia frequency. Transcainide is a promising new antiarrhythmic drug which should be used with caution in patients with conduction disorders and impaired cardiac function. Its value and safety in the chronic oral treatment of life-threatening arrhythmias remains to be established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637668
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Molecular and functional diversity of cloned cardiac potassium channels (1993)
    Springer
    Cardiovascular drugs and therapy 7 (1993), S. 585-592 
    Details
    ISSN: 1573-7241
    Keywords: K+ channel ; IT0 ; delayed rectifier ; antiarrhythmic drugs ; cardiac excitation-contraction coupling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Action potential duration is an important determinant of refractoriness in cardiac tissue and thus of the ability to propagate electrical impulses. Action potential duration is controlled in part by activation of K+ currents. Block of K+ channels and the resultant prolongation of action potential duration has become an increasingly attractive mode of anti-arrhythmic intervention. Detailed investigation of individual cardiac K+ channels has been hampered by the presence of multiple types of K+ channels in cardiac cells and the difficulty of isolating individual currents. We have approached this problem by employing a combination molecular cloning technology, heterologous channel expression systems, and biophysical analysis of expressed channels. We have focused on six different channels cloned from the rat and human cardiovascular systems. Each channel has unique functional and pharmacological characteristics, and as a group they comprise a series of mammalian K+ channel isoforms that can account for some of the diversity of channels in the mammalian heart. Each channel appears to be encoded by a different gene with little or no evidence for alternate splicing of RNA transcripts to account for the differences in primary amino acid sequence. In addition to the unique kinetic properties of these channel isoforms when expressed as homotetrameric assemblies, the formation of heterotetrameric K+ channels is also observed. The formation of heterotetrameric channels from the different gene products to create new channels with unique kinetic and pharmacological properties might further account for cardiac K+ channel diversity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00877624
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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