ISSN:
1572-8854
Keywords:
Synthetic steroids
;
progesterone analogs
;
antifertility profiles
Source:
Springer Online Journal Archives 1860-2000
Topics:
Geosciences
,
Physics
Notes:
Abstract The title compound (C19H26N2O2) is one of a series of novel heteroatom steroidal derivatives recently prepared for testing their antifertility profiles and progesterone binding affinity. It is one of a pair of epimers differing in configuration at position 5. The X-ray analysis has uniquivocally resolved this ambiguity. The compound crystallizes in space group P212121, a = 9.257(3), b = 9.419(3), c = 19.089(5)Å, and Z = 4 and the structure was solved by direct methods. In the steroid skeleton Ring A does not exhibit the chair conformation commonly found in the steroid nucleus, being considerably strained, presumably as a consequence of the fused planar oxadiazole ring E. Rings B and C, however, are chairs and ring D is in an intermediate envelope/half-chair conformation. All rings of the steroid skeleton are trans connected.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1021856309954
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