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  • 1
    Digitale Medien
    Digitale Medien
    Synthesis, characterization and in vitro antitumor activity of dimethyl-, diethyl, and di-t-butyl-tin(IV) derivatives of substituted salicylic acids (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 5 (1991), S. 497-506 
    Details
    ISSN: 0268-2605
    Schlagwort(e): Diorganotin ; salicylic acid ; NMR ; Mössbauer ; antitumor ; Chemistry ; Industrial Chemistry and Chemical Engineering
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The synthesis of dimethyl-, diethyl- and/or di-t-butyl-tin(IV) derivatives of substituted salicylic acids of the type a, (X-Y-2-OH-C6H2COO)2SnR2 (X, Y = H, H; H, 5-CH3; H, 5-Cl; H, 5-F; H, 3-CH3O; H, 5-CH3O; 3-CH3, 6-(CH3)2CH; 3,5-[(CH3)2CH]2 and 4,5-benzo) and b {[R2(X-Y-2-OH-C6H2COO)Sn]2O}2 (X, Y = H, 3-CH3O; H, 5-CH3O: 3-CH3, 6-(CH3)2CH; 3,5-[(CH3)2CH]2 and 4,5-benzo) is reported. Their characterization by 1H, 13C and 119Sn NMR, Mössbauer and mass spectrometry is described. The in vitro antitumor activity of selected derivatives against two human tumoral cell lines, MCF-7 and WiDr, is presented.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aoc.590050607
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  • 2
    Digitale Medien
    Digitale Medien
    In vitro antitumour activities of a novel 2:3 condensation product of salicylaldoxime with di-n-butyltin(IV) oxide (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 6 (1992), S. 197-205 
    Details
    ISSN: 0268-2605
    Schlagwort(e): Organotin ; antitumor ; salicylaldoxime ; butyltin ; phenyltin ; Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The antitumor activities of three novel condensation products of salicylaldoxime with di-n-butyltin(IV) oxide (compound 1), di-t-butyltin oxide (compound 2) and diphenyltin oxide (compound 3) are presented. Against MCF-7, a human mammary tumor cell line, compounds 1 and 2 are characterized by inhibition doses ID50 in vitro of 67 and 49 ng cm-3 respectively, whereas cis-platin, an antitumor drug used clinically, has an ID50 of 850 ng cm-3. Against WiDr, a colon carcinoma, they also score better than cis-platin: 215 and 121 ng cm-3 versus 624 ng cm-3. In contrast, the diphenyltin compound, 3, is inactive against both tumor cell lines.The results of a pre-screening performed on compound 1 by the National Cancer Institute (NCI) on a panel of 60 human tumor cell lines show that two of the selectivity parameters calculated by the NCI for that compound are statistically significant, namely DG150 (51.9〉50) and MGDH (80.1〉75). One is almost satisfactory (DH = 72.4 = ca75). The other two, DTGI (40.0〈50) and DLC50 (16.7〈50) are not. (Abbreviations are explained in the text and in Gielen, M. and Willem, R. Anticancer Res., 1992, in press).
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aoc.590060214
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