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  • Radiation-induced osteosarcoma  (1)
  • application approval rates  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Establishment and characterization of C-type RNA virus-producing cell lines from radiation-induced murine osteosarcomas (1979)
    Springer
    Journal of cancer research and clinical oncology 94 (1979), S. 149-162 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Cell line ; Radiation-induced osteosarcoma ; Mice ; C-type RNA virus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Eight cell lines were established from murine osteosarcomas induced in vivo with the radionuclides 224Ra and 227Th. They have been compared by light and electron microscopy, by karyology, and by their growth properties. The morphology, the growth pattern, and the ability to induce tumors in mice indicate that five of them are tumor cell lines. Chromosome studies demonstrated that the five cell lines have marker chromosomes. The other cell lines only showed some criteria generally used to score for transformation of fibroblasts and they may be derived from stromal cells. All cell lines release virus particles in the culture fluid which have the typical properties of RNA tumor viruses. They possess C-type morphology, a density of 1.16–1.18 g/cm3, a 60–70 S RNA, a RNA dependent DNA polymerase and they induce syncytia in rat XC cells. The possible significance of these virus particles in radiation osteosarcomagenesis is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00422495
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Quantitative evaluation of peer review of program project and center applications in allergy and immunology (1985)
    Springer
    Journal of clinical immunology 5 (1985), S. 220-227 
    Details
    ISSN: 1573-2592
    Schlagwort(e): Program projects and centers ; peer review ; application approval rates ; priority scores ; variability in scores
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We compared the review patterns of applications for program projects and centers in allergy and immunology, reviewed by the National Institute of Allergy and Infectious Diseases review committee, with those of individual research projects in immunology, reviewed by three Division of Research Grants study sections. A high concordance between these review groups was obtained with respect to the application approval rate, mean score, and distribution of applications in various priority score ranges. Furthermore, we observed a high degree of consensus among reviewers on the quality of many program project and center applications, especially those with priority scores between 100 and 200.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00929456
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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