Digitale Medien
New York, NY
:
Wiley-Blackwell
Proteins: Structure, Function, and Genetics
12 (1992), S. 237-265
ISSN:
0887-3585
Schlagwort(e):
β-sheet-coil transition
;
β-hairpin
;
Langevin dynamics
;
equilibrium properties
;
quasiparticle
;
effective potential
;
autocorrelations
;
cross-correlations
;
time histories
;
rate constants
;
Chemistry
;
Biochemistry and Biotechnology
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Medizin
Notizen:
A simplified model of a polypeptide chain is used to study the dynamics of the β-sheet-coil transition. Each amino acid residue is treated as a single quasiparticle in an effective potential that approximates the potential of mean force in solution. The model is used to study the equilibrium and dynamic aspects of the sheet-coil transition. Systems studied include ones with both strands free to move (two-strand sheet), and ones with either strand fixed in position (multistrand sheet). The equilibrium properties examined include sheet-coil equilibrium constants and their dependence on chain position. Dynamic properties are investigated by a stochastic simulation of the Brownian motion of the chain in its solvent surroundings. Time histories of the dihedral angles and residue-residue cross-strand distances are used to study the behavior of the sheet structure. Auto-and cross-correlation functions are calculated from the time histories with relaxation times of tens to hundreds of picoseconds. Sheet-coil rate constants of tens of ns-1 were found for the fixed strand cases.
Zusätzliches Material:
20 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/prot.340120304
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