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  • baculovirus  (3)
  • carbohydrate antigens  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Glycoconjugate journal 13 (1996), S. 693-707 
    ISSN: 1573-4986
    Schlagwort(e): mucin glycoproteins ; mucin genes ; carbohydrate antigens ; cancer ; metastasis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Mucins are high molecular weight glycoproteins that are heavily glycosylated with many oligosaccharide side chains linked O-glycosidically to the protein backbone. With the recent application of molecular biological methods, the structures of apomucins and regulation of mucin genes are beginning to be understood. At least nine human mucin genes have been identified to date. Although a complete protein sequence is known for only three human mucins (MUC1, MUC2, and MUC7), common motifs have been identified in many mucins. The pattern of tissue and cell-specific expression of these mucin genes are emerging, suggesting a distinct role for each member of this diverse mucin gene family. In epithelial cancers, many of the phenotypic markers for pre-malignant and malignant cells have been found on the carbohydrate and peptide moieties of mucin glycoproteins. The expression of carbohydrate antigens appears to be due to modification of peripheral carbohydrate structures and the exposure of inner core region carbohydrates. The expression of some of the sialylated carbohydrate antigens appears to correlate with poor prognosis and increased metastatic potential in some cancers. The exposure of peptide backbone structures of mucin glycoproteins in malignancies appears to be due to abnormal glycosylation during biosynthesis. Dysregulation of tissue and cell-specific expression of mucin genes also occurs in epithelial cancers. At present, the role of mucin glycoproteins in various stages of epithelial cell carcinogenesis (including the preneoplastic state and metastasis), in cancer diagnosis and immunotherapy is under investigation.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Journal of chemical ecology 25 (1999), S. 2193-2204 
    ISSN: 1573-1561
    Schlagwort(e): Heliothis virescens ; chlorogenic acid ; HzSNPV ; baculovirus ; phenolics ; tritrophic interactions ; plant defense
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract The effects of chlorogenic acid on larval survival and growth of the tobacco budworm Heliothis virescens and larval susceptibility to Helicoverpa zea nucleopolyhedrovirus (HzSNPV) were studied with an artificial diet and transgenic tobacco Nicotiana tabacum. Survival of neonates on over- or underexpressed phenylalanine ammonia-lyase (PAL) transgenic tobacco lines was positively correlated with the level of chlorogenic acid. Larval weight was not correlated with the level of chlorogenic acid in tobacco foliage. On the other hand, larval weights on artificial diet supplemented with chlorogenic acid were negatively correlated with chlorogenic acid concentration. Second instars treated on virus-treated (10 occlusion bodies/larva) tobacco leaf disks for 24 hr and then reared on tobacco leaves showed higher survival time and increased mortality on lines with increasing levels of chlorogenic acid. However, viral-related larval mortality on artificial diet was negatively correlated with dietary chlorogenic acid. These results illustrate the inadequacy of artificial diet studies in establishing causal relationships among plant chemistry, herbivores, and natural enemies.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1573-8248
    Schlagwort(e): Nuclear polyhedrosis virus ; baculovirus ; Heliothis zea ; soybean ; virus transmission ; Virus de polyédrose nucléaire ; baculovirus ; Heliothis zea ; soja ; transmission d'un virus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Beschreibung / Inhaltsverzeichnis: Résumé La transmission d'un virus de polyédroses nucléaires (NPV) a été examinée dans des populations deHeliothis zea (Boddie) de même âge et dans des populations deHeliothis zea d'âges variés relâchées sur du soja en cages. Des collections de larves ont montré des incidents d'infection virale dans tous les traitements après la remise en liberté des larves infectées (les lères larves infectées). La transmission du NPV dans des populations de même âge a été relative à la densité des lères larves infectées qui ont été relâchées dans la population mais n'a pas été relative à la taille, au moment de leur mort, des lères larves infectées (P〈0.05). Dans des populations d'âges variés, la transmission horizontale chez les larves les plus âgées de la population a été égale à celle des populations de même âge, à condition que les lères larves infectées dans la population d'âges variés aient été toutes de même âge que les membres noninfectés les plus âgés de la population. A mesure que la population d'âges variés vieillit, la transmission augmente et est, en général, plus élevée que celle des populations de même âge. La transmission a été aussi plus élevée quand les lères larves infectées étaient de taille moyenne au moment de leur mort que lorsqu'elles étaient de taille petite ou grande au moment de leur mort. La concentration du virus déposée sur le feuillage et dans le sol après la mort de toutes les larves a été mise en corrélation avec la densité des lères larves infectées qui ont été relâchées. La concentration du virus dans le sol, mais pas sur le feuillage, a été mise en corrélation avec la taille, au moment de leur mort des lères larves infectées qui ont été relâchées.
    Notizen: Abstract Transmission of a nuclear polyhedrosis virus (NPV) was examined in uniformaged and uniform- vs mixed-age populations ofHeliothis zea (Boddie) on caged soybean. Larval collections revealed viral disease outbreaks occurred in all treatments following release of infected larvae (Primary infected larvae). Transmission of NPV in uniform-aged populations was related to the density of primary infected larvae released in the population but not to the size at death of primary infected larvae (P〈0.05). In mixed-age populations horizontal transmission in the oldest larvae in the population was equal to that in uniform-aged populations, providing that primary infected larvae in the mixed-aged population were all the age of the oldest noninfected cohorts. As the mixed-age population aged, transmission increased and was generally higher than that in the uniform-aged populations. Transmission was also higher when primary infected larvae were medium sized at death than when small or large at death. The concentration of virus deposited on foliage and in soil after all larvae had died on plants was related to density of primary infected larvae released. In soil, but not on foliage, the virus concentration was related to the size at death of primary infected larvae released.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    ISSN: 1573-8248
    Schlagwort(e): nuclear polyhedrosis virus ; baculovirus ; Heliothis zea ; soybean ; virus transmission
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Beschreibung / Inhaltsverzeichnis: Résumé La transmission d'un Virus de Polyhédroses Nucléaires (NPV) chezHeliothis zea sur soja a été examinée. Des contaminations artificielles deH. zea ont été réalisées aux densités de 6.5, 19.5 et 58.5 larves/rangée-m. Des larves supplémentaires inoculées de NPV pour mourir au 2e stade larvaire ont été relâchées dans des subdivisions d'un champ pour simuler des niveaux de mortalité de 5 et de 25%. La transmission du virus des larves infectées aux larves non infectées a été mise en corrélation avec l'incidence initiale de l'infection dans la population, mais pas avec la densité des larves/rangée-m. Le dépôt de virus sur les plantes à partir des cadavres de larves mortes de l'infection virale a été mis en corrélation avec la densité de larves/rangée-m et l'incidence initiale de l'infection dans les populations. Après la chrysalidation des larves dans la première population, seules des larves non-infectées ont été de nouveau relâchées pour examiner la transmission del'inoculum du virus restant sur les plantes et dans le sol. Le pourcentage de mortalité des larves récoltées de ce deuxième lâcher était peu élevé et n'a pas différé de manière significative entre les traitements. La concentration du virus sur le feuillage et dans le sol après le deuxième lâcher a été mise directement en corrélation avec la densité de larves/rangée-m, mais pas avec l'incidence de l'infection dans la population du premier lâcher.
    Notizen: Abstract Transmission of a nuclear polyhedrosis virus (NPV) inHeliothis zea (Boddie) on soybean was examinated. Artificial infestations ofH. zea were established at densities of 6.5, 19.5 and 58.5 larvae/row-m. Additional larvae infected to die from NPV in the 2nd stage were released into subplots to simulate 5 and 25% mortality levels. Virus transmission from infected to noninfected larvae was correlated with the initial incidence of infection in the population but not the density of larvae/row-m. Deposition of virus on plants from cadavers of larvae that died of virus infection was correlated with the initial incidence of infection in the populations and the density of larvae/row-m. After pupation of larvae in the 1st population, noninfected larvae only were again released to examine transmission of viral inoculum remaining on plants and soil. The percent mortality of larvae collected from the 2nd release was low and did not differ significantly between treatments. The concentration of virus on foliage and in soil after the 2nd release was directly correlated with density of larvae/row-m but not the incidence of infection within the population in the 1st release.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 50 (1992), S. 91-96 
    ISSN: 0730-2312
    Schlagwort(e): carbohydrate antigens ; chemoprevention ; colorectal cancer antigens ; intermediate biomarker ; mucin glycoproteins ; Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Considerable alteration of cellular carbohydrates such as glycolipids and glycoproteins occurs in colonic neoplasia. Some of these changes are also observed at certain embryonic stages of differentiation and are, therefore, considered onco-developmental changes. In colon cancer cells, many of the phenotypic markers for malignancy have been found on carbohydrate moieties, and some have been found on the peptide portion of mucin glycoproteins. The changes in carbohydrate antigens include altered expression of core region carbohydrates, extension of backbone structures and modification of peripheral carbohydrate structures that may arise due to abnormal glycosylation processes. Altered glycosylation may also result in the exposure of the peptide moiety of the mucin glycoprotein. Therefore, these altered mucin glycoprotein structures may serve as tumor markers. Howerver, it remains to be determined whether they will be useful as intermediate endpoint markers.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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