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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of intelligent manufacturing 11 (2000), S. 285-294 
    ISSN: 1572-8145
    Keywords: SCADA ; HOOD ; real-time monitoring and control ; control C++ ; inheritance ; polymorphism.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Most recent researches into an object oriented design approach for the development of real-time Supervisory Control and Data Acquisition (SCADA) applications have concentrated on object identification and object classification. These techniques, however, may only be considered as an object-based paradigm. In the true object-oriented paradigm, object characteristics such as data encapsulation, inheritance and polymorphism must also be considered. This paper introduces a design paradigm for developing a SCADA system through the true object oriented design methodology. To complete the design, a hierarchical object-oriented design (HOOD) tree is used to map the physical shop floor layout to a logical layout for formulating the basic object hierarchy. The active components and control logic in the SCADA models are manipulated by a newly derived script language called CONTROL-C++ proposed by the author. To verify the proposed model, a newly designed software system is implemented and justified in terms of system completeness and soundness.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-6830
    Keywords: basal ganglia ; AMPA-type glutamate receptor ; ribosome inactivating protein ; trichosanthin ; immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 1. To investigate the potency of a novel immunotoxin that is specific for glutamate receptor GluR1, a subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA)-type receptor channel, immunolesioning was performed. 2. A ribosome-inactivating protein, trichosanthin (TCS), was isolated and conjugated to the goat anti-rabbit IgG antibody molecule. The anti-rabbit antibody–TCS complex was preincubated with GluR1-specific rabbit antibody to produce a GluR1-specific immunotoxin. The immunotoxin was unilaterally administered into either the neostriatum or the lateral ventricle of rats. 3. Immunoreactivity for GluR1 or GluR4 was revealed in perfuse-fixed sections of the neostriatum obtained from the lesioned and control animals by immunocytochemistry. After ventricular or striatal injections of the immunotoxin, depletions of GluR1-immunoreactive neurons, the presumed GABAergic interneurons in the neostriatum, were found. Depletions of GluR4-immunoreactive perikarya, the presumed same subpopulation of striatal interneurons, were also found. In addition, no change in the pattern of distribution of immunoreactivity for GluR2 or glial fibrillary acidic protein was found in the lesioned neostriatum. These results indicate that the novel GluR1 immunotoxin is potent and specific. 4. In addition, striatal application of the immunotoxin caused a greater depletion in the number of GluR1-immunoreactive neurons. The present results also indicate that the route of immunotoxin application may be important in producing specific lesions.
    Type of Medium: Electronic Resource
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