ISSN:
1432-1041
Schlagwort(e):
indomethacin
;
lysine salt
;
controlled release formulation
;
plasma concentration
;
bioavailability
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Medizin
Notizen:
Summary The bioavailability of a new controlled release formulation of indomethacin lysine salt in tablets was tested in 6 healthy humans against a conventional indomethacin lysinate formulation in capsules. Both contained 100 mg of the drug, i.e. 70 mg indomethacin. Peak plasma levels were lower and more lasting and the AUC was higher with the new controlled release formulation. The latter on average produced active plasma levels for 12 h, and so it can be recommended for twice daily administration.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00609963
Permalink