ISSN:
1573-8744
Keywords:
area analysis
;
pharmacokinetic model
;
rate constant determination
;
biotransformation products
;
computer simulation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The principle of area analysis was used in the development of a metabolic and pharmacokinetic model for an extensively biotransformed drug. Area analysis was also used to determine the rate constants associated with the model. The drug used to exemplify the utility of area analysis in developing such a model was N4-ethoxyacetylsulfamethoxazole. Administration of this drug to the monkey results in three recognizable biotransformation products. Each of the four compounds was administered intravenously to a monkey on separate occasions. Excellent agreement was obtained between the simulated and actual blood levels of the intact drug and its three biotransformation products. Such agreement between the simulated and experimental data reflects the utility of area analysis as the basis for the design of a metabolic and pharmacokinetic model.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01062347
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