Digitale Medien
Springer
International journal of peptide research and therapeutics
5 (1998), S. 143-145
ISSN:
1573-3904
Schlagwort(e):
bombesin
;
cholecystokinin
;
conformational constraints
;
novel tryptophan derivatives
;
tachykinin
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Summary Our aim is to identify and synthesise a ‘family’ of tryptophan mimetics which thoroughly explore chi space and then incorporate them into selected ligands for biological receptors e.g. Tachykinin NK1. This project is considered important as only the ψ-ø angles have previously been explored; obtaining a greater understanding of the spacial orientation of the side chain in chi space (x 1-X2) should prove invaluable to the future design of peptidomimetics. The amino acid tryptophan was selected as it has proved pivotal in many pharmaceutic drug programmes.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02443457
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