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  • 1
    Electronic Resource
    Electronic Resource
    Synthesis and phosphorylation of androgen receptor of the mouse brain cortex and their regulation by sex steroids during aging (2000)
    Springer
    Molecular and cellular biochemistry 203 (2000), S. 95-101 
    Details
    ISSN: 1573-4919
    Keywords: aging ; AR phosphorylation ; AR synthesis ; brain cortex ; sex steroids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract To examine the synthesis and phosphorylation of androgen receptor (AR) and their regulation by sex steroids, adult (24 weeks) and old (65 weeks) male and female mice were gonadectomized and administered with testosterone and estradiol. AR amount, synthesis and phosphorylation were measured in the brain cortex by immunoblotting and immunoprecipitation using antibody raised against rat AR transactivation domain (TAD) which was expressed in E. coli as a fusion protein. We found that the amount of AR was high in adult and declined in old mice of both sexes. Administration of testosterone and estradiol significantly down-regulated the level of AR in old male and adult female. Similarly, the rate of AR synthesis also declined with age. Exogenous treatment of gonadectomized mice with testosterone and estradiol reduced the extent of synthesis significantly in all groups except in old female. No sex-dependent variation was noticed either in the level or synthesis of AR. In contrast, the extent of phosphorylation was higher in old mice of both sexes as compared to their adult counterparts. Testosterone and estradiol supplementation resulted in remarkable increase in AR phosphorylation in all groups. Thus it is evident from our findings that the amount and synthesis of AR decrease but phosphorylation of AR increases in the brain cortex with advancing age of mice and they are regulated by testosterone and estradiol in age and sex-specific manner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007064307220
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  • 2
    Electronic Resource
    Electronic Resource
    Landslide hazard susceptibility mapping based on terrain and climatic factors for tropical monsoon regions (2000)
    Springer
    Bulletin of engineering geology and the environment 58 (2000), S. 275-287 
    Details
    ISSN: 1435-9537
    Keywords: Key words Residual material ; Colluvium ; Basalt ; Monsoon area ; Weightings ; Landslide hazard zonation ; Mots clés Formations résiduelles ; Colluvions ; Basalte ; Région de mousson ; Zonage de l'aléa ; Glissement de terrain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Résumé Une altération météorique intense du substratum, des formations résiduelles et colluvions, des intensités de pluies aléatoires, sont les principaux facteurs responsables des glissements de terrain dans les régions tropicales de mousson. Les conditions d'un développement durable de ces régions nécessitent des informations sur la répartition spatiale des zones sujettes aux glissements de terrain. Ces facteurs ne sont pas pris en considération dans la pratique de la cartographie de l'aléa glissement de terrain. Cette étude met en lumière divers aspects propres aux glissements qui ont lieu sur la côte ouest de l'Inde, ainsi que la méthodologie développée pour cet objectif.
    Notes: Abstract  Deep weathering, residual material (colluvium) and random rainfall intensity are mainly responsible for landslides in tropical monsoon regions. These parameters are often not taken into consideration in a landslide susceptibility assessment. Sustainable resources development in this region requires information on the spatial distribution of areas susceptible to landslides. This study highlights various aspects of the landslides that take place on the west coast of India and a methodology developed for landslide susceptibility mapping.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100649900032
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    Paper (German National Licenses)
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