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  • Chemical Engineering  (4)
  • cell growth  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Growth of animal cells around hollow fibers: Multifiber studies (1993)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 39 (1993), S. 1415-1419 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690390820
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    An investigation of the diffusion-limited growth of animal cells around single hollow fibers (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 40 (1992), S. 1233-1242 
    Details
    ISSN: 0006-3592
    Keywords: hollow fiber bioreactors ; cell growth ; hybridoma cells ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: To compare modeling with experimental data of cell growth surrounding individual fibers, the growth profiles of hybridoma cells in the extracapillary space of single hollow fiber bioreactors were examined. Agarose was provided in the extracapillary space to provide support and minimize convection. By sacrificing bioreactors at various time intervals, the growth profiles of cells surrounding a single hollow fiber could be monitored with increasing time. Using photomicroscopy and viable staining, areas of viable and nonviable cell growth were examined at various stages of development ranging from initial seeding to stable growth conditions. Cells were found to act as nucleation sites for the growth of individual colonies within the agarose. Profiles at stable growth conditions resulted in a thick cell mass near the surface of the fiber wall followed by cell colonies of decreasing size with increasing radial distance. A simplified theoretical model for cell growth was developed using mass balance equations for substrate penetration into individual cell colonies as well as away from the wall of a single fiber. The resulting profiles derived from theory were compared with experiments and found to be in good agreement for entering oxygen concentrations of 5% and 20%. © 1992 John Wiley & Sons, Inc.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260401013
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    An experimental investigation of stability and multiplicity of steady states in a biological reactor (1981)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 27 (1981), S. 284-292 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The existence of multiple stable and unstable steady states in a continuous stirred tank biological reactor (CSTBR) was demonstrated experimentally for the first time. These experiments resulted in the determination of growth rate, yield and intermediate metabolite concentration data entirely from continuous culture. This information was used to qualitatively interpret the stability behavior in terms of the biochemistry and bioenergetics of substrate metabolism.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690270216
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Phase-plane analysis of feedback control of unstable steady states in a biological reactor (1978)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 24 (1978), S. 686-693 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Feedback control of an open loop, unstable, continuous flow, stirred-tank biological reactor was investigated theoretically using several microbial growth models. The closed loop system can be made globally stable, but constraints on the manipulated variable can lead to as many as five steady states, which are either saddle points or locally stable nodes.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690240417
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Constrained control of an unstable biological reactor (1984)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 30 (1984), S. 520-522 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690300333
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    Paper (German National Licenses)
    Fulltext
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