ISSN:
1435-1463
Keywords:
NMDA receptor
;
synaptogenesis
;
cerebellum
;
activity-dependent mechanisms
;
Purkinje cells
;
granule cells
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary To analyze the affect of blocking neuronal activity on NMDA receptor levels during development, we have injected chick embryos with the competitive NMDA receptor antagonist NPC 12626 from E17 to E19. Brains from drug-treated (n=7) and control (n=6) embryos (E20) were processed for receptor autoradiography using the NMDA competitive antagonist [3H]CGP 39653. NPC 12626 treatment caused a significant 24 to 46% increase in [3H]CGP 39653 binding in both the forebrain and cerebellar cortex. The results support the hypothesis that NMDA receptor levels are regulated by activity-dependent mechanisms.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01271185
Permalink
