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  • chemotherapy  (4)
  • Lycopersicon esculentum  (3)
  • Physical Chemistry  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Postinfectional changes of lipids and photosynthesis in Lycopersicon esculentum susceptible to Phytophthora capsici
    Amsterdam : Elsevier
    Plant Science 61 (1989), S. 169-178 
    Details
    ISSN: 0168-9452
    Keywords: Lycopersicon esculentum ; Phytophthora capsici ; chlorophylls ; fatty acids ; photosynthesis ; plant-pathogen interaction
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-9452(89)90221-5
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  • 2
    Electronic Resource
    Electronic Resource
    Polar lipids in healthy and Phytophthora capsici-infected leaflets of Lycopersicon esculentum
    Amsterdam : Elsevier
    Phytochemistry 31 (1992), S. 1961-1967 
    Details
    ISSN: 0031-9422
    Keywords: Lycopersicon esculentum ; Phytophthora capsici ; Solanaceae ; fatty acids ; glycoglycerolipids ; oomycete ; phospholipids ; plant-pathogen interactions ; polar lipids.
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(92)80342-C
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  • 3
    Electronic Resource
    Electronic Resource
    Pigment evolution in Lycopersicon esculentum fruits during growth and ripening
    Amsterdam : Elsevier
    Phytochemistry 14 (1975), S. 2357-2362 
    Details
    ISSN: 0031-9422
    Keywords: Lycopersicon esculentum ; Solanaceae ; carotenoids ; chlorophylls. ; maturation ; plastids ; tomato fruit
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(75)80344-X
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  • 4
    Electronic Resource
    Electronic Resource
    Sixteen week dose intense chemotherapy for inoperable, locally advanced breast cancer (1993)
    Springer
    Breast cancer research and treatment 28 (1993), S. 277-284 
    Details
    ISSN: 1573-7217
    Keywords: breast cancer ; chemotherapy ; dose-intensity ; inflammatory breast cancer ; locally advanced breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Up to 15% of women with breast cancer have locally advanced disease at diagnosis. The poor response of these patients to local therapy alone and the frequent development of disseminated disease suggest that early intensive systemic therapy may benefit these women. Twenty-four patients with non-metastatic, locally advanced, primarily inflammatory, inoperable breast cancer were treated with a 16-week dose-intense chemotherapy regimen as induction therapy. Treatment consisted of 8 repetitive 2-week cycles consisting of 100 mg/m2 cyclophosphamide orally D1-7, 40 mg/m2 doxorubicin intravenously (IV) D1, 1 mg vincristine IV D1, 100 mg/m2 methotrexate IV D1, 10 mg/m2 leucovorin every 6 hours for six oral doses D2-3, and 600 mg/m2 5-FU IV over 2 hours D2. A continuous infusion of 300 mg/m2 5-FU per day was given IV D8-9 of each 2-week cycle. After induction all patients had at least a partial clinical response and were operable; 9/24 (37%) achieved a clinical complete response. All patients underwent at least a simple mastectomy. Pathologic examination revealed no evidence of gross macroscopic tumor in 11/24 patients (46%) and no evidence of microscopic disease in 4/24 patients (17%). Seven of 24 patients (29%) had no microscopic disease in the breast. At a median follow-up of 45 months, there have been 10 relapses in the 24 patients treated with this induction regimen. The actuarial relapse-free survival at 5 years is 58%. Actuarial overall survival at 5 years is 75%. We conclude that this regimen is safe and well-tolerated and that the results of this therapy are sufficiently promising to warrant further study of this regimen in patients with locally advanced breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00666589
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  • 5
    Electronic Resource
    Electronic Resource
    Phase II study of cisplatin and 5‐fluorouracil in previously treated metastatic breast cancer: an Eastern Cooperative Oncology Group study (PA 185) (1999)
    Springer
    Breast cancer research and treatment 57 (1999), S. 201-206 
    Details
    ISSN: 1573-7217
    Keywords: chemotherapy ; cisplatin ; 5‐fluorouracil ; metastatic breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: The present study was conducted to investigate the efficacy and toxicity of a cisplatin and 5‐fluorouracil (5‐FU) combination in previously treated advanced breast cancer. Methods: Thirty‐six women with recurrent metastatic breast cancer were entered on a phase II study of 5‐FU 1000 mg/m2/day given intravenously as a continuous infusion on days 1–3 and cisplatin 30 mg/m2/day given intravenously over 1 h on days 2–4, repeated every 21 days. All subjects had received one previous chemotherapy regimen for metastatic disease and either progressed during treatment or relapsed after responding to previous chemotherapy. Fourteen patients had also received previous adjuvant chemotherapy, 17 patients had previous radiation therapy, and 29 patients had previous hormonal therapy. Results: Among 32 response‐evaluable patients, there were 10 partial remissions (31%) and 1 complete remission (3%), with an overall objective response rate of 34%. Median duration of response was 4 months. Median survival was 10.5 months for responders and 9.5 months for the entire group. Toxicity was mild to moderate in most patients. Overall twelve patients experienced grade 3 toxicity (10 hematologic, 1 mucositis, and 2 nausea). There were no grade 4 or 5 toxicities. Conclusion: Infusional cisplatin and 5‐FU is a well tolerated and active regimen in women with previously treated advanced breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006229701954
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  • 6
    Electronic Resource
    Electronic Resource
    Treatment of stage III breast cancer (1989)
    Springer
    Breast cancer research and treatment 13 (1989), S. 225-235 
    Details
    ISSN: 1573-7217
    Keywords: chemotherapy ; combination therapy ; hormonal synchronization ; locally advanced breast cancer ; preoperative chemotherapy ; prognosis ; radiotherapy ; staging, surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A major question in oncology today concerns the most appropriate therapy for locally advanced breast cancer. Realistic goals include effective local treatment and a prolonged disease-free interval for these patients, most of whom have incurable disease. Here, our panel discusses the roles of surgery, radiation therapy, chemotherapy, and hormonal therapy, and the proper sequencing of these modalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02106572
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  • 7
    Electronic Resource
    Electronic Resource
    Adjuvant therapy in node-negative breast cancer (1989)
    Springer
    Breast cancer research and treatment 13 (1989), S. 97-115 
    Details
    ISSN: 1573-7217
    Keywords: adjuvant therapy ; chemotherapy ; clinical trials ; estrogen receptor ; node-negative breast cancer ; prognostic factors ; tamoxifen ; toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01806522
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  • 8
    Electronic Resource
    Electronic Resource
    Kinetic study of the reaction of IO with CH3SCH3 (1987)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 19 (1987), S. 503-512 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reaction IO + CH3SCH3 → products (3) was studied at room temperature and near 1 Torr pressure of He, using the discharge flow mass spectrometric technique. The rate constant was found to be k3 = (1.5 ± 0.5) × 10-11 cm3 molecule-1 s-1. CH3S(O)CH3 was detected as a product suggesting the following channel: IO + CH3SCH3 → CH3S(O)CH3 + I. The rate constant of the reaction IO + IO → products (1) was also measured: k1 = (3 ± 0.5) × 10-11 at 298 K and 1 Torr pressure. The atmospheric implication of reaction (3) is discussed. The results indicate that this reaction could be a potential important sink of CH3SCH3 in marine atmosphere.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550190603
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  • 9
    Electronic Resource
    Electronic Resource
    Kinetic study for the reactions of OH radicals with dimethylsulfide, diethylsulfide, tetrahydrothiophene, and thiophene (1985)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 17 (1985), S. 1247-1261 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reactions of OH radicals with dimethylsulfide (DMS) diethylsulfide (DES), tetrahydrothiophene (THT), and thiophene have been studied at room temperature for DES and THT, at 273, 293, and 318 K for DMS, and at 293 and 318 K for thiophene by the discharge flow EPR technique in a halocarbon wax coated reactor. The following rate constants were obtained at room temperature. For the reaction OH + DMS (1), a very low temperature dependence was noticed.Some additional results concerning the mass spectrometric analysis of the products are also reported.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550171202
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  • 10
    Electronic Resource
    Electronic Resource
    Kinetics and mechanism for the reactions of H atoms with CH3SH and C2H5SH (1988)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 20 (1988), S. 897-907 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A kinetic study of the reactions of H atoms with CH3SH and C2H5SH has been carried out at 298 K by the discharge flow technique with EPR and mass spectrometric analysis of the species. The pressure was 1 torr. It was found: k1 = (2.20 ± 0.20) × 10-12 for the reaction H + CH3SH (1) and k2 = (2.40 ± 0.16) × 10-12 for the reaction H + C2H5SH (2). Units are cm3 molecule-1 s-1. A mass spectrometric analysis of the reaction products and a computer simulation of the reacting systems have shown that reaction (1) proceeds through two mechanisms leading to the formation of CH3S + H2 (1a) and CH3 + H2S (1b).
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550201108
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