ISSN:
1573-2568
Keywords:
hepatocellular carcinoma
;
chronic hepatitis
;
HBV DNA
;
viral DNA integration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In a series of 325 HBV chronically infected children observed over an 18-year period, three developed HCC. These three children were born in southern Italy, a region characterized by a high endemic HBV infection rate; each had been infected perinatally, developed an acute hepatitis, and became a chronic carrier. Two of the three with cirrhosis were HBsAg positive at the time their HCC was detected. The remaining case had seroconverted to HBsAb but HBV-DNA integration could be demonstrated in the absence of cirrhosis; moreover HBV antigens were not expressed in the tissue of this case. The interval between HBV infection and HCC appearance in these three cases ranged from six to 11 years. A similarity between these three Italian cases and the majority of HCC, arising in chronically infected children in the Far East is noted.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01297462
Permalink
