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Physiological pharmacokinetic modeling ofcis-dichlorodiammineplatinum(II) (DDP) in several species (1986)

King, Franklin G. ; Dedrick, Robert L. ; Farris, Fred F.

Springer

Journal of pharmacokinetics and pharmacodynamics 14 (1986), S. 131-155

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ISSN: 1573-8744

Keywords: pharmacokinetics ; physiological model ; cisplatin ; DDP ; cis-dichlorodiammineplatinum(II)

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract A physiological pharmacokinetic analysis ofcis-dichlorodiammineplatinum(II) (DDP) is presented for the rabbit, dog, and human. The results are compared to a previous analysis for the rat. DDP binds irreversibly to low-molecular weight nucleophiles and macromolecules to form mobile and fixed metabolites at rates which are tissue-specific. The rate constant for the formation of fixed metabolite in plasma, determined by in vitro incubation, ranges from 0.004 to 0.008 min−1.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01065258

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