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  • 1
    ISSN: 1432-2072
    Keywords: Slow wave sleep ; 5-HT2/1c receptor ; Ritanserin ; ICI 169,369 ; Home sleep recordings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of the selective 5-HT2 receptor antagonists, ritanserin (1, 5 and 10 mg) and ICI 169,369 (50 and 100 mg), were studied on the sleep EEG of healthy volunteers using home-based Medilog 9000 cassette monitoring. Ritanserin (5 and 10 mg) produced a significant increase in slow wave sleep (SWS) while ICI 169,369 also increased SWS but only at a dose of 100 mg. These findings are consistent with the proposal that selective 5-HT2 receptor blockade increases SWS in humans; however, the data cannot exclude involvement of the closely related 5-HT1c receptor in this effect.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2072
    Keywords: Anxiety ; Slow wave sleep ; Ritanserin ; 5-HT2 receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eight patients with generalised anxiety disorder (GAD) and eight matched healthy controls had their polysomnogram measured on two occasions separated by 1 week. On one occasion they received the 5-HT2 receptor antagonist, ritanserin (5 mg orally) and on the other matching placebo. The increase in slow wave sleep produced by ritanserin was the same in GAD patients as in healthy controls. These findings do not support the hypothesis that GAD is associated with a generalised hypersensitivity of brain 5-HT2 receptors; however, the present data cannot exclude the presence of a regionally specific change in this receptor subtype in anxiety disorders.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-5117
    Keywords: macroinvertebrates ; sampling methods ; wetlands ; classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Macroinvertebrate communities sampled by a corer, plankton net and sweep net from five wetlands on the Swan Coastal Plain were compared. The composition of the fauna collected in sweeps and tows was generally similar and differed from that collected in the cores. Cores caught fewer species than tows and sweeps at all wetlands and did not capture fast swimming hemipterans or less abundant taxa. The highest species richness was recorded in sweep samples in four out of the five wetlands. Classification (TWIN-SPAN) and ordination (SSH) of the samples collected in sweeps and tows gave good separation of the wetlands, whereas classification of core samples did not. Coring appeared to be the least suitable sampling method for describing the major components of the macroinvertebrate communities of these wetlands. Plankton tows were useful if the time available for sorting was limited as these samples were free of sediments and generally gave similar results to those obtained with sweeps. Sweeps appeared to be the most useful method for a large classification study as they collected more species and resulted in the best discrimination amongst wetlands.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Mathematical geology 22 (1990), S. 573-588 
    ISSN: 1573-8868
    Keywords: classification ; regionalization ; Bayes' theorem ; geostatistics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Mathematics
    Notes: Abstract The concept of multivariate classification of “geological objects” can be combined with the concept of regionalized variables to yield a procedure for typification of geological objects, such as rock units, well records, or samples. Numerical classification is followed by subdivision of the area of investigation, and culminates in a regionalization or mapping of the classification onto the plane. Regions are subdivisions of the map area which are spatially contiguous and relatively homogeneous in their geological properties. The probability of correct classification of each point within a region as being part of that region can be assessed in terms of Bayesian probability as a space-dependent function. The procedure is applied to subsurface data from western Kansas. The geologic properties used are quantitative variables, and relationships are expressed by Mahalanobis' distances. These functions could be replaced by other metrics if qualitative or binary data derived from geological descriptions or appraisals were included in the analysis.
    Type of Medium: Electronic Resource
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