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  • 1
    Electronic Resource
    Electronic Resource
    Effect of bilateral adrenalectomy on VIP receptor/effector system in rat intestinal epithelial cells (1990)
    Springer
    Bioscience reports 10 (1990), S. 165-171 
    Details
    ISSN: 1573-4935
    Keywords: adrenalectomy ; dexamethasone ; VIP ; cyclic AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The number of vasoactive intestinal peptide (VIP) receptors and the efficiency of VIP in the stimulation of cyclic AMP accumulation in rat jejunal epithelial cells increased after bilateral adrenalectomy. However, this condition increased neither receptor affinity nor VIP potency. In addition, jejunal VIP levels followed a parallel increase. These changes reversed to control conditions after glucocorticoid replacement with dexamethasone indicating that adrenalectomy modifies the intestinal VIP receptor/effector system and suggest a relationship between corticosteroids and VIP in the functions of intestinal epithelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01116575
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of experimental uremia in rats on duodenal VIP levels and the interaction of VIP with duodenal epithelial cells (1989)
    Springer
    Bioscience reports 9 (1989), S. 207-212 
    Details
    ISSN: 1573-4935
    Keywords: VIP ; cyclic AMP ; uremia ; enterocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The effects of experimental uremia on the concentration of vasoactive intestinal peptide (VIP) in duodenum as well as on the interaction of this neuropeptide with the corresponding epithelial cells were studied in rats. Duodenal VIP concentration was significantly decreased in uremic rats as compared to control animals. The specific binding of VIP to duodenal epithelial cells increased in rats with uremia due to an increase in the number of VIP receptors rather than a change in the binding affinity or in the extent of VIP degradation. On the other hand, the efficacy but not the potency of VIP upon cyclic AMP generation varied in parallel to that observed at the receptor level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01115997
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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