Electronic Resource
Springer
Breast cancer research and treatment
52 (1998), S. 17-28
ISSN:
1573-7217
Keywords:
cyclin D
;
cyclin E
;
DCIS
;
prevention
;
tumor progression
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Cyclins are regulatory subunits for cyclin dependent kinases in the coordination of the cell cycle. Cyclins can also serve non-cell cycle functions, such as the transactivation of estrogen receptor by cyclin D. Evidence for the participation of the G1 cyclins D and E in breast cancer is summarized, including transgenic and knockout mice, transfections, and expression patterns in cohort studies. Overexpression of cyclin D has been reported in ductal carcinoma in situ (DCIS), and similar overexpression of cyclin E is suggested. Strategies to reduce cyclin expression are discussed as potential prevention efforts.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1006102916060
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