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  • 1
    Electronic Resource
    Electronic Resource
    Intravenous self-administration of cocaine and norcocaine by dogs (1980)
    Springer
    Psychopharmacology 71 (1980), S. 83-89 
    Details
    ISSN: 1432-2072
    Keywords: Self-administration ; Dogs ; Cocaine ; Norcocaine ; d-Amphetamine ; Phenoxybenzamine ; Pimozide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The potency of cocaine, relative to d-amphetamine, to initiate and maintain intravenous self-administration behavior by dogs (n=5) was determined. Response-contingent infusions of cocaine (at unit doses of 0.15, 0.30 and 0.60 mg/kg/infusion) and d-amphetamine (at unit doses of 0.05 and 0.10 mg/kg/infusion) were available during daily 4-h sessions on a FR1 reinforcement schedule. By comparing the dose-response curves of the two drugs, it was found that 1 mg of amphetamine is equivalent to 5.3 mg of cocaine (95% confidence limits=3.8–9.1 mg). In a second experiment, pretreatment with the α-adrenergic antagonist phenoxybenzamine (in doses ranging from 0.125–2.0 mg/kg, IV) did not produce any appreciable changes in responding for cocaine (0.2 mg/kg/infusion) by dogs (n=9). In contrast, when the same animals were pretreated with the dopaminergic antagonist pimozide (in doses ranging from 5–40 mg/kg, IV), subsequent responding for cocaine was increased in a dose-dependent manner. In a third experiment it was determined that norcocaine, the N-demethylated metabolite of cocaine, would maintain self-administration behavior by dogs (n=4) when it was substituted for cocaine. As expected, when saline was substituted for cocaine, responding was not maintained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433258
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of psychomotor stimulants on single-spatial alternation behavior in dogs (1979)
    Springer
    Psychopharmacology 63 (1979), S. 137-141 
    Details
    ISSN: 1432-2072
    Keywords: Single-spatial alternation ; Dog ; Relative potency ; Methylphenidate ; Cocaine ; d-Amphetamine ; Phenmetrazine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dogs were trained to pedal press for drinking water in a noncued, single-spatial alternation task. After the dogs were exhibiting stable performance at or above predetermined criteria levels, they were given three doses of four different drugs (methylphenidate, 0.2, 0.4, and 0.8 mg/kg; d-amphetamine, 0.15, 0.3, and 0.6 mg/kg; cocaine, 0.5, 1, and 2 mg/kg; and phenmetrazine, 0.6, 1.2, and 2.4 mg/kg). In general, all four drugs produced similar changes in performance. The number of correct responses was an especially sensitive indicator of drug effects. All four drugs also produced significant increases in both the average response latency and total session duration, but there were few significant changes in either the total number of responses or number of intertrial interval responses. Relative to d-amphetamine, the potencies of cocaine and phenmetrazine, but not methylphenidate, were generally higher for the measures of single-spatial alternation than for self-administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429691
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Self-administration of CNS stimulants by dog (1975)
    Springer
    Psychopharmacology 43 (1975), S. 207-213 
    Details
    ISSN: 1432-2072
    Keywords: Self-Administration ; Dog ; d-Amphetamine ; Phenmetrazine ; Methylphenidate ; Parallel Line Bioassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Drug-naive dogs were trained to respond for intravenous infusions of either d-amphetamine, phenmetrazine, or methylphenidate until a stable response rate per 4-hr daily session was achieved. The magnitude of reinforcement (i.e., mg/kg/infusion) was then varied systematically across a wide range for each drug. An inverse relationship between unit dose and number of self-administered infusions per session was seen. Thus, total drug intake per session remained relatively constant and was independent of unit dose. Using a parallel line bioassay design, the relative potencies of d-amphetamine, phenmetrazine, and methylphenidate to maintain self-administration were estimated. By comparing the unit doses of d-amphetamine which yielded the same rate of self-administration it was found that 1 mg of phenmetrazine is equivalent to 0.1 mg of d-amphetamine. It was also determined that 1 mg of methylphenidate is equivalent to 0.75 mg of d-amphetamine. These data indicate the dog can be used to assess the reinforcing properties of psychomotor stimulants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429252
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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