ISSN:
1573-8744
Keywords:
cephapirin
;
desacetylcephapirin
;
cephalosporin
;
renal clearance calculations
;
renal metabolism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A pharmacokinetic model was developed to describe the absorption, distribution, metabolism, and excretion of cephapirin and its major metabolite, desacetylcephapirin, following intravenous and intramuscular administration of cephapirin in healthy adult subjects. The model involved a two-compartment open model for cephapirin in plasma and extravascular tissues and included metabolism of cephapirin to desacetylcephapirin in both the plasma compartment and the kidney. Renal metabolism of cephapirin was followed by excretion of the desacetylcephapirin into the urine. Clearance calculations and digital computer simulation supported these features of the model.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01059474
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