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Digitale Medien

Effect of dose size on amodiaquine pharmacokinetics after oral administration (1987)

Winstanley, P. A. ; Edwards, G. ; Orme, M. L′E. ; [weitere]

Springer

European journal of clinical pharmacology 33 (1987), S. 331-333

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Details

ISSN: 1432-1041

Schlagwort(e): amodiaquine ; desethylamodiaquine ; first-order pharmacokinetics

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary Plasma and urine concentrations of amodiaquine (AQ) and desethylamodiaquine (AQm) have been measured after oral administration of AQ 200, 400 and 600 mg in randomised order to 6 healthy subjects. The relationships between AQ dose size and the areas under the plasma concentration vs time curves for AQ and AQm were linear. Likewise there were linear relationships between AQ dose size and the mass of both AQ and AQm excreted in the urine. These data indicate that after oral administration within this dose range AQ displays first-order pharmacokinetics.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00637573

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