ISSN:
1573-8221
Keywords:
liver monooxygenases
;
resistance to hypoxia
;
antipyrine
;
nifedipine
;
diazepam
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Rats with low and high resistance to hypoxia are shown to differ in terms of the baseline activity of liver monooxygenases bothin vivo andin vitro. Low-resistance animals are characterized by a significantly higher rate of elimination of antipyrine, hexenal, and nifedipine, as evidenced by shorter half-elimination period and higher urinary concentration of metabolites. The concentration of microsomal cytochromes P-450 and b5 as well as the rates of N-demethylation of amidopyrine, p-hydroxylation of aniline, and hydroxylation of diazepam are considerably higher in rats with low resistance to hypoxia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02446578
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