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  • 1
    Digitale Medien
    Digitale Medien
    Peptide loading in the endoplasmic reticulum accelerates trafficking of peptide: MHC class II complexes in B cells (1999)
    Springer
    Journal of biomedical science 6 (1999), S. 53-63 
    Details
    ISSN: 1423-0127
    Schlagwort(e): MHC class II ; Invariant chain ; Class II:peptide complexes ; Intracellular trafficking
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract In a combination of biochemical and immunoelectron-microscopical approaches we studied intracellular trafficking and localization of the endoplasmic-reticulum (ER)-formed complexes of murine MHC class II molecule I-Ab and an antigenic peptide Eα52–68 covalently linked to its β-chain. The association with the peptide in the ER leads to sharp acceleration of the intracellular trafficking of the complexes to the plasma membrane. Within the cells, Eα52–68:I-Ab complexes accumulate in the multivesicular MHC class II compartment (MIIC), but not in denser multilaminar or intermediate type MIICs. The changes in the trafficking of ER-formed complexes result solely from the presence of the tethered peptide, since wild-type class II molecules traffic similarly in bare lymphocyte syndrome cells and in wild-type antigen-presenting cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02256424
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Crown Ether-Dinitrile Interaction: An X-ray Study (1999)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 33 (1999), S. 331-338 
    Details
    ISSN: 1573-1111
    Schlagwort(e): dicyclohexano-18-crown-6 ; succinonitrile ; glutaronitrile ; crystal structure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Formation of the host-guest compounds between isomers of dicyclohexano-18-crown-6 as hosts (DC18C6) and various dinitriles as guests has been observed. The structures of two representative compounds (cis-anti-cis-DC18C6...2(NCCH2CH2CN) ( I) and (cis-syn-cis-DC18C6...(NCCH2CH2CH2CN) ( II) were obtained using X-ray diffractometry. Crystal data: ( I) P=¯1, a = 8.586(3), b = 9.324(3), c = 10.714(4) Å α = 72.47(3)°, β = 73.57(3)°, γ = 72.37(3), R1 = 0.034, GooF 1.08, Z = 1; ( II) Pbca, a = 12.881(5), b = 17.887(8), c = 23.042(13) Å, R1 = 0.049, GooF 1.02, Z = 8. Both structures show weak C–-H...O interactions between α-methylene protons of dinitrile guest molecules and oxygen atoms of the macrocyclic host ring.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008092602058
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