ISSN:
1573-904X
Keywords:
dissolution of water-insoluble drugs
;
dissolution of griseofulvin, carbamazepine, clofibrate, medroxyprogesterone, cortisone acetate
;
dissolution with sodium lauryl sulfate
;
dissolution with surfactants
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The determination of the in vitro release profile of water-insoluble drug products requires dissolution media different from those used for water-soluble drug products. Since the relevance of drug dissolution in organic solvents is questionable, we investigated the use of surfactants to determine the dissolution profiles of water-insoluble drug products. In most cases, the drug dissolution rate and extent increased as the surfactant concentration in the aqueous dissolution medium increased. Suitable dissolution profiles were obtained in the presence of sodium lauryl sulfate (SLS) for water-insoluble drug products, such as griseofulvin, carbamazepine, clofibrate, medroxyprogesterone, and cortisone acetate. These findings recommend the use of surfactants for determining the aqueous dissolution of water-insoluble drug products rather than adding organic solvents to the dissolution medium.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015909716312
Permalink
