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The Prophylactic Mastectomy Dilemma: A Support Group for Women at High Genetic Risk for Breast Cancer (1999)

Karp, Jane ; Brown, Karen L. ; Sullivan, Margaret D. ; [et al.]

Springer

Journal of genetic counseling 8 (1999), S. 163-173

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ISSN: 1573-3599

Keywords: prophylactic mastectomy ; breast cancer ; women at high genetic risk for breast cancer ; psychiatric evaluation ; psychosocial support ; support group ; genetic counseling ; education and health promotion

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine , Psychology

Notes: Abstract The goal of this pilot study was to test the usefulness of a six session psychoeducational support group for women at high genetic risk for breast cancer who were considering prophylactic mastectomy. The themes of the group sessions included overestimation of and anxiety about risk; desire for “hard data”; the emotional impact of watching a mother die of breast cancer; concerns about spouse reactions; self- and body image; the decision-making process; and confusion over whom to trust in decision making. Both the participants and the multidisciplinary leaders concluded that as a supplement to individual counseling, a support group is a beneficial and cost-effective treatment modality. Recommendations for the optimal format for such a group are described.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1022834706495

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Regulation of expression of the growth-state-related genes 2F1 and 2A9 during entry of quiescent smooth muscle cells into the cell cycle (1991)

Kindy, Mark S. ; Brown, Karen E. ; Sonenshein, Gail E.

New York, N.Y. : Wiley-Blackwell

Journal of Cellular Biochemistry 46 (1991), S. 345-350

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ISSN: 0730-2312

Keywords: SMCs ; mRNA ; mitochondrial ADP/ATP carrier ; calcyclin ; cell cycle ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: Vascular smooth muscle cells (SMCs) play a key role in the development of major arteries. Furthermore, abnormal growth of vascular smooth muscle cells has been implicated in the progression of major diseases of the cardiovascular system. Here, we report detection in primary cultures of bovine vascular smooth muscle cells of mRNA for two growth-state-related genes, 2F1 and 2A9, which code for a mitochondrial ADP/ATP carrier and calcyclin, respectively, and on the characterization of their cell cycle expression. Cultures of exponentially growing smooth muscle cells were made quiescent by serum deprivation. Upon readdition of serum, cells entered the cell cycle synchronously; DNA synthesis began 12 h post-serum addition. Levels of 2F1 and 2A9 RNA were low in quiescent cells and increased between 2 and 4 h post-serum addition. No changes in the rates of transcription of the 2F1 or 2A9 genes were detected by nuclear run-off assays during the time course. Thus the regulation of changes in expression of 2F1 and 2A9 in early G1 is mediated post-transcriptionally.

Additional Material: 3 Ill.