ISSN:
0899-0042
Schlagwort(e):
enantiomeric separation
;
chiral phase
;
ovomucoid
;
octahydrobenzo(g) quinoline
;
chiral recognition mechanism
;
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
The enantiomeric resolution of six closely related hexa- and octa-hydrobenzo(g) quinoline racemates by HPLC on an ovomucoid column (Ultron ES-OVM) is described. First, the influence of uncharged mobile phase additives (with different hydrogen bonding properties) and pH on retention and enantioselectivity is investigated. It is shown that an optimum pH of around 6 for the given separations is much more important than the choice of modifier. Second, the influence on enantioselectivity of small differences in molecular structure is examined. In one case a large difference is obtained for diastereomeric racemates depending on the cis- or trans-configuration of the quinoline skeleton. Higher flexibility of the solute seen in the cis enantiomers seems to improve enantioselectivity. © 1993 Wiley-Liss, Inc.
Zusätzliches Material:
3 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/chir.530050108
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