ISSN:
1420-9071
Keywords:
Deoxycholic acid
;
heparin
;
enteral absorption
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Sodium deoxycholate (DOC), selected as a promoter of gastrointestinal absorption of heparin, was administered orally to rats, followed, at increasing intervals, by heparin. Maximal plasma clearing activity (PC) was obtained with a 60-min interval, though PC was still elicited after 24 h, suggesting that DOC acts on the gastrointestinal mucosa. Inhibition of blood coagulation was also observed after oral heparin. The suggestion that DOC increases heparin absorptions is supported by increased plasma levels of heparin. No signs of several gastrointestinal damage were seen.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02004499
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