ISSN:
1573-8221
Keywords:
liver microsomes
;
tocopherol
;
glutathione
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Tocopherol-enriched liver microsomes are more resistant to lipid peroxidation at an alkaline pH of 8.5 in comparison with microsomes incubated at pH 7.5. An alkaline pH provides conditions for two-electron oxidation of tocopherol, which causes the lipid molecule to revert to the initial state (O2/H exchange). A possible mechanism of inhibition of lipid peroxidation within the physiological range of pH with participation of a glutathione-dependent enzyme is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02445013
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