ISSN:
1432-0428
Keywords:
Biguanide
;
radioglucose incorporation
;
glycogen
;
rat diaphragm
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary After a short term oral administration of 25 mg buformin per animal (100–125 mg/kg/day) and final intraperitoneal injection of glucose we found a significantly increased content of glycogen in the diaphragm of normal male and female rats together with a higher incorporation of glucose. The latter effect was not observed if the last dose of buformin was given 24 h before the investigation. No effect on glycogen content or glucose incorporation into the glycogen was measurable after daily administration of 2.5 mg buformin per animal for 14 days or a single dose of 25 mg buformin per animal. The present investigation confirms the clinical experience that the effect of biguanides is seen only after some days of treatment.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01219984
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