ISSN:
1573-2568
Keywords:
serology
;
gastritis
;
Helicobacter pylori
;
healthy volunteers
;
pepsinogens
;
gastrin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract This study was undertaken in healthy volunteers to determine the relation between serum levels of pepsinogen A, pepsinogen C, pepsinogen A:C ratio, and gastrin on the one hand and histology of the gastric mucosa on the other. The grade of gastritis was scored separately for antral and fundic mucosa by three different classifications: Whitehead, activity, and the Sydney score. Among 48 healthy volunteers studied, 17 were found to have gastritis according to the criteria of Whitehead. Fourteen of these 17 subjects with gastritis hadH. pylori in gastric biopsies. In all 48 subjects serum pepsinogen A (r=0.298−0.506;P〈0.01−P〈0.05), pepsinogen A:C ratio (r between −0.377 and −0.495;P〈0.001−P〈0.05) and gastrin (r=0.38−0.695;P=0.007−P〈0.01) were significantly correlated to the severity of both antral and body gastritis as assessed by all three classifications. In contrast, there was no significant correlation between serum pepsinogen C and any of the gastritis scores. When the 17 subjects with gastritis were analyzed separately, there were no correlations between the parameters studied and gastritis of the antrum. Regarding the corpus mucosa, serum PgA correlated significantly with the activity score (r=0.520;P=0.03), weakly with the Sydney score (r=0.465;P=0.06), but not with the Whitehead score. Serum PgC correlated with the Whitehead (r=0.555;P=0.02) and Sydney score (r=0.523;P=0.03), but only weakly with the activity score (r=0.441;P=0.08). The pepsinogen A:C ratio showed only a weak inverse correlation with the Whitehead gastritis score (r=−0.471;P=0.06), but not with the two other scores. Serum gastrin was significantly correlated with the Whitehead (r=0.634;P=0.006) and the Sydney score (r=0.501;P=0.04), but not with the activity score of the fundic mucosa. It is concluded that among healthy volunteers with gastritis, serological parameters are only correlated to the severity of corpus but not of antral gastritis. Serum PgC and gastrin correlated to the severity of corpus gastritis only if atrophy is comprised in the classification. In contrast, serum PgA correlates only with the activity of corpus gastritis. Thus, serological parameters reflect specific histologic features of gastritis of the gastric body, but not of the antrum.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02064379
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