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  • Methyl(triisocyanato)silane  (1)
  • hypoxia  (1)
Materialart
Erscheinungszeitraum
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Journal of inorganic and organometallic polymers and materials 2 (1992), S. 143-149 
    ISSN: 1572-8870
    Schlagwort(e): Methyl(triisocyanato)silane ; ammonolysis ; polysilazane ; precursor ; silicon nitride
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The synthesis and properties of polymethylsilazanes were investigated. Controlled ammonolysis of methyl(triisocyanato)silane (MTIS) at the molar ratios NH3/MTIS=4 and 6 gave polymethylsilazanes3 and4, which were soluble in tetrahydrofuran (THF) and dimethyl sulfoxide (DMSO) but insoluble when isolated as powders. The concentrated polymer solution showed spinnability and film formation. Thermogravimetric analysis of3 and4 showed weight losses of 67 and 16%, respectively. Species4 may be a precursor for silicon/carbon/nitrogen ceramics.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1573-675X
    Schlagwort(e): Apoptosis ; cell cycle ; hypoxia ; radiosensitizer.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract PR-000350, a novel hypoxic radiosensitizer, is a 2-nitroimidazole nucleoside analog and has begun to be used for clinical cancer therapy. In this study, using U937 monoblastoid cells we investigated the mechanisms of enhanced cell killing by PR-000350. When cells were irradiated under an extremely hypoxic condition, the apoptotic rate was strongly suppressed. However, a remarkable increase in the DNA fragmentation rate as well as in the ladder formation was observed when hypoxic cells were irradiated in the presence of 5 mM PR-000350. DNA histograms of the PR-000350 treated group showed enhancement of the sub-G1 fraction and simultaneous suppression of the progression of the cell cycle from the S to G2/M phase at 4–8 h after X-irradiation, suggesting the importance of the S phase in the induction of apoptotic cell death. Flow cytometric and immunohistochemical analyses after BrdU labelling revealed that apoptotic cell death is induced mainly in the BrdU-positive cells. In addition, by using cell synchronization technique it was proved that the S phase is the most sensitive fraction to the radiosensitizing effect of PR-000350. These results suggest that PR-000350 strongly enhances tumor cell killing by promoting X-ray induced-apoptosis preferentially in the S-phase fraction. PR-000350 is a new type radiosensitizer and promise to provide an effective anti-cancer activity against hypoxic tumor cells that are resistant to the usual radiotherapy.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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