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Digitale Medien

Goniothalamicin and annonacin: Bioactive acetogenins fromGoniothalamus giganteus (Annonaceae) (1988)

Alkofahi, A. ; Rupprecht, J. K. ; Smith, D. L. ; [weitere]

Springer

Cellular and molecular life sciences 44 (1988), S. 83-85

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Details

ISSN: 1420-9071

Schlagwort(e): Goniothalamicin ; annonacin ; acetogenins ; Goniothalamus giganteus ; Annonaceae ; brine shrimp ; insecticidal ; cytotoxic ; antileukemic activity

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary Using brine shrimp lethality for activity-directed fractionation, goniothalamicin (I), a new tetrahydroxy-mono-tetrahydrofuran fatty acid γ-lactone (acetogenin), has been isolated from ethanolic extracts of the stem bark ofGoniothalamus giganteus Hook. f., Thomas (Annonaceae). This novel compound was found to be cytotoxic and insecticidal and inhibited the formation of crown gall tumors on potato discs. Annonacin (II), the only other reported mono-tetrahydrofuran acetogenin, was also isolated; the previously reported 9ASK (astrocytoma reversal) activity ofII was confirmed, andII is now also found to be weakly active against 3PS murine leukemia.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01960258

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