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  • 1
    ISSN: 1432-0428
    Schlagwort(e): Isolated fat cells ; insulin ; trypsin treatment ; plasma membranes ; amino acid incorporation ; amino acid mixture
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Incorporation of 0.1 mM3H-leucine into protein by isolated fat cells, with pyruvate as the only extracellular carbohydrate, was stimulated by: a) insulin, 0.1–4 ng/ml, or b) a mixture of 19 amino acids, 0.05–5 mM. Treatment of fat cells with trypsin, under conditions known to reduce binding of insulin by their plasma membranes, abolished stimulation of incorporation by the hormone but not by the amino acid mixture. These results imply that the actions of insulin on incorporation of amino acids into protein are initiated by interaction with plasma membranes.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Psychopharmacology 142 (1999), S. 73-77 
    ISSN: 1432-2072
    Schlagwort(e): Key words Mice ; 5-HT ; Somatodendritic 5-HT1A receptor ; 8-OH-DPAT ; Hypothermia ; Adrenalectomy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Complex interactions exist between the hypothalamic-pituitary-adrenal (HPA) axis and the serotonergic system, and it has been suggested that these interactions may be fundamental to the pathophysiology and treatment of depressive illnesses. It has previously been found that chronic administration of corticosterone leads to adrenal suppression and an attenuation of somatodendritic 5-HT1A receptor function. Adrenalectomy (ADX) has been shown to cause an increase in postsynaptic 5-HT1A receptor numbers and possibly function. However, other reports have suggested that ADX does not alter somatodendritic 5-HT1A receptor mRNA or binding, though little is known of the effect of ADX on the function of somatodendritic 5-HT1A receptors. This study investigated the effect of markedly reducing corticosterone levels by ADX on 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT)-induced hypothermia in mice, an in vivo model of somatodendritic 5-HT1A receptor function. The degree of 8-OH-DPAT-induced hypothermia did not differ between control, sham, and ADX animals 14 days post operatively. Although repeated administration of corticosterone attenuates somatodendritic 5-HT1A receptor function, these data demonstrate that lowering of corticosteroid levels by ADX have no effect. This suggests that the effects of repeated corticosterone administration is not mediated by a secondary adrenal suppression. The difference in the effects of ADX on somatodendritic as opposed to postsynaptic 5-HT1A receptors may reflect the differential expression of corticosteroid receptor subtypes at postsynaptic and somatodendritic sites.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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