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  • 1
    Electronic Resource
    Electronic Resource
    Onchocerciasis (1990)
    Springer
    International ophthalmology 14 (1990), S. 189-194 
    Details
    ISSN: 1573-2630
    Keywords: onchocerciasis ; blindness ; ivermectin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Onchocerciasis is a devastating blinding disease caused by the parasite Onchocerca volvulus that infects about 80 million people, causing blindness and visual impairment in 1–2 million people. In hyperendemic areas, more than half of the population will become blind from onchocerciasis before they die. Blindness is the most important effect of the disease and results, in part, from direct invasion of the eye by microfilariae. The recent development of ivermectin has revolutionized our ability to treat this disease. An annual oral dose of only 150 mg/kg completely suppresses the disease manifestations. Programs for the community-based mass distribution of ivermectin are now being conducted and promise to control this major blinding scourge.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00158317
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Onchocerciasis — A potential revolution in its treatment (1987)
    Springer
    International ophthalmology 11 (1987), S. 83-85 
    Details
    ISSN: 1573-2630
    Keywords: onchocerciasis ; treatment ; ivermectin ; vector control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Onchocerciasis is a major blinding disease affecting at least 28 million people in Africa and Latin America. Although a large-scale vector control program has been highly successful in limiting transmission of infection in West Africa, there has not been a satisfactory form of treatment available for those already infected or those living in other areas. Despite the fact that two drugs, diethylcarbamazine and suramin, are active against the filarial parasite that causes onchocerciasis, their use is severely limited by their toxicity and the reaction they induce. A newly developed drug, ivermectin, appears to offer a major revolution in the treatment of onchocerciasis. In a series of clinical trials, ivermectin has been shown to be an extremely effective microfilaricide which induces only minimal side effects. Ivermectin is given as a single oral dose which can be repeated on an annual basis. In view of its safety and efficacy and its ease of administration, it seems likely that ivermectin will be suitable for use in mass chemotherapy programs against onchocerciasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00136735
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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