ISSN:
1432-1459
Keywords:
l-DOPA treatment
;
Monoamine metabolites in CSF
;
Parkinson's disease
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary HVA, the main dopamine catabolite, was shown to be decreased in CSF of parkinsonian patients. A significant relationship was also shown between clinical improvement and HVA concentration increase in CSF. It was, however, recently claimed that such increase was not specific. A study on the CSF concentrations of HVA and 5-HIAA (the main serotonin metabolite) was undertaken on 10 parkinsonian patients. The determinations were made before and after l-DOPA therapy, when a satisfactory clinical status was achieved. The results obtained clearly demonstrate that a large increase of HVA was found in CSF during l-DOPA therapy, but no relationship was found between HVA levels and clinical improvement. A decrease of 5-HIAA in CSF during l-DOPA treatment was found. These results are discussed in the light of a relationship between dopamine and serotonin during l-DOPA therapy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00315939
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