ISSN:
1573-4927
Keywords:
β-glucuronidase
;
lysosomal enzymes
;
mucopolysaccharidosis
;
glycosaminoglycans
;
mice
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract Young (60–80 days) mice of the low β-glucuronidase strain, C3H/HeJ, showed no differences in hepatic levels of glycosaminoglycans (GAGs) when compared to the randombred, “normal” Swiss-Webster mice of the same age. However, by 12 months of age hepatic GAG is nearly twice as high in C3H/HeJ mice as in Swiss-Webster mice. Studies of β-glucuronidase, β-galactosidase, and N-acetyl-β-glucosaminidase in four tissues of the two types of mice at the two ages revealed that glucuronidase was the only enzyme with lower activity in the C3H/HeJ strain.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00484528
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