ISSN:
1573-1111
Keywords:
Solid-state esterolysis
;
α-cyclodextrin
;
mitrophenyl acetates
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The esterolysis ofm-nitrophenyl acetate (mNPA) andp-nitrophenyl acetate (pNPA), complexed with α-cyclodextrin, was investigated in the solid state. At 117 and 140°C, the initial half-times ofmNPA esterolysis were 30 and 24 h, respectively, whereasp NPA esterolysis was undetectably slow. At 117°C, themNPA reaction proceeded to completion, and cyclodextrin acetate andm-nitrophenol products were identified. At 140°C,the initial rate was followed by a slow phase with a half-time of 130 h, evidently due to a structural change in the complex. Themeta/para selectivity of the solid-state reaction is considerably enhanced over the selectivity reported in aqueous solution.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00660746
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