ISSN:
1420-9071
Keywords:
SCID mice
;
Pneumocystis carinii
;
immunodeficiency
;
pneumonia
;
monoclonal antibodies
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract clinically healthy SCID mice were infected intratracheally withPneumocystis carinii (PC) of human origin. The data obtained provides unambiguous evidence that progressive multiplication of PC organisms of human origin takes place in the lungs of experimentally infected animals. SCID mice that were infected with human-derived PC also revealed a markedly greater number of mouse PC organisms in their lungs than the controls. All the SCID recipients of human PC died by day 65 post infection, whereas the controls, housed under identical conditions, started dying significantly later due to severe mouse pneumocystosis. This animal model could be used for the maintenance and propagation of human PC, and for evaluating strategies for treating human pneumocystosis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01923610
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