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  • 1
    ISSN: 1573-1561
    Keywords: Achillea millefolium ; mosquito larvicides ; Aedes triseriatus ; unsaturated amides ; N-(2-methylpropyl)-(E,E)-2,4-decadienamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A methanol extract ofAchillea millefolium L. showed activity against 24-hr-old larvae ofAedes triseriatus. Bioassay- and TLC-monitored fractionation yielded a neutral fraction which was refined further by column chromatography to afford the antilarvalN-(2-methlpropyl)-(E,E)-2,4-decadienamide which was identified by spectral methods and through comparisons with a synthesized sample. Isolated and synthesized amides at 5 ppm resulted in 98 and 100% mortality of 24-hr-oldA. triseriatus larvae. TheN-(2-methylpropyl)-amides of decanoic and (E)-2-decenoic acids showed the same order of antilarval activity asN-(2-methylpropyl)-(E,E)-2,4-decadienamide, butN-(2-methylpropyl)sorbamide was inactive.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-1561
    Keywords: Cladophora glomerata ; difunctional carboxylic acids ; Aedes triseriatus ; mosquito larvicides ; GC-MS detection ; fatty acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A study to identify the acidic components ofCladophora glomeata active againstAedes triseriatus larvae was extended to a mixture obtained by extracting the dried powdered alga in aqueous suspension at pH 8.5. The presence of 1,9-nonanedioic, 1,10-decanedioic, 1,11-undecanedioic and 4-ketononanoic acids was determined by GC-EIMS and GC-CIMS and confirmed by analytical coinjection GC. The presence of 5-pentyldihydro-2(3H)-furanone, a minor component, was also indicated. The group of major acidic constituents is different from those obtained by extracting driedCladophora with methanol. In contrast to the C10–C14 monocarboxylic acids, which hadLD 50 values〈20 ppm againstA. triseriatus, none of the dicarboxylic acids of the series G4–C14, C16, and C22 were active; nor were 4-ketononanoic acid and 5-pentyldihydro-2(3H)-furanone active.
    Type of Medium: Electronic Resource
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